Hillman Group
Dunwoody Dentist, sedation dentist, childrens dentist
OVERVIEW
Oragenics, Inc. is a publicly-traded biopharmaceutical company with a pipeline of unique proprietary technologies and a primary focus on commercialization. The corporate strategy is to bring products to market as quickly as possible and use the proceeds to further the development and commercialization of the remaining technologies. In addition to marketed products based on the ProBiora3 technology, the Company also has a number of products in discovery, preclinical and clinical development, with a concentration in the main therapeutic area of infectious diseases, in diagnostics, and in oral health. Oragenics has developed platform technologies with respect to its products, thereby creating a potential pipeline of future products, which the Company expects to develop.
A BRIEF HISTORY
Dr. Jeffery Hillman began his basic research into the concept of Replacement Therapy for preventing dental caries or cavities in the late 1970′s at the Forsyth Dental Center in Boston. He transferred his research to the University of Florida College of Dentistry in 1992. There, he continued to pursue the development of a genetically engineered strain of Streptococcus mutans that could both prevent cavities and replace the bodies natural caries-causing strains of S .mutans.
Dr. Hillman and Dr. Robert Zahradnick founded Oragenics at the end of 1996 to commercialize the fruits of 25 years of research.
A major product is SMaRT Replacement Therapyâ¢
Most human tooth decay is caused by a bacterium called Streptococcus mutans that sits on the tooth surface and converts sugar in a personâÂÂs diet to lactic acid. The lactic acid is excreted by the bacteria and causes tooth decay by dissolving the mineral that comprises the enamel and dentin. Dr. Hillman and his research team have isolated a strain of S. mutans that produces a small amount of an antibiotic that is capable of killing all other strains of this species. Through recombinant DNA technology, Dr. HillmanâÂÂs group succeeded in eliminating the gene in this strain that is responsible for producing lactic acid. Consequently, it does not cause significant tooth decay. This genetically modified strain will be used in an approach called replacement therapy to eliminate decay-causing strains of S. mutans, with the possibility of providing life-long protection from a single, five minute treatment.
Technical Background. Many different types of bacteria reside in everyoneâÂÂs mouth. Streptococcus mutans (S. mutans) is a bacterium that resides on nearly everyoneâÂÂs teeth. This bacteria converts sugar that a person eats into lactic acid. Lactic acid erodes the toothâÂÂs enamel and causes the great majority of tooth decay. Oragenicsâ replacement therapy technology consists of a genetically modified strain of S. mutans that does not produce lactic acid. This strain of S. mutans produces tiny quantities of a substance known as Mutacin 1140, which allows the strain to out-compete any other strain of S. mutans that is naturally resident on a personâÂÂs teeth. The strain eliminates the resident S. mutans and replaces them in the mouth. The manufacturing approach for producing the SMaRT strain of S. mutans for use in Oragenics replacement therapy technology relies on standard fermentation methods. The finished product. Following regulatory review and marketing approval as a new drug, will be administered as a pharmaceutical composition by dentists during office visits. Administration will consist simply of swabbing the SMaRT strain onto the patientâÂÂs teeth using a cotton tipped applicator for a five minute period. Because the SMaRT strain will establish itself in the patientâÂÂs mouth and out-compete resident strains on the teeth, one treatment may last for a lifetime.
Preclinical Studies. Laboratory and animal studies of the effectiveness of Oragenicsâ replacement therapy technology have been conducted in rats for almost 30 years. In one of these studies, the SMaRT strain of S. mutans and wild-type strains of s. mutans were grown in the laboratory in the presence of sugar. After careful analysis of the culture, it was found that the wild-type strain made lactic acid almost exclusively from the metabolism of sugar, as well as very small amounts of other acids and non-acidic compounds. By contrast, the SMaRT strain made mostly the non-acidic compounds and produced absolutely no detectable lactic acid. Dr. HillmanâÂÂs group then infected two identical groups of conventional rats with either the wild strain or the SMaRT strain. A third identical group of rats was not infected and served as a control group. After feeding the rats a diet containing sugar for eight weeks, the teeth of the rats were carefully inspected to determine their incidence and severity of tooth decay. It was found that animals infected with the SMaRT strain had no more tooth decay than did the control group animals. Both the group infected with the SMaRT strain and the control group has only a small fraction of the tooth decay experienced by the wild-type strain.
Oragenicsâ scientists have demonstrated that the SMaRT strain can eliminate disease-causing S. mutans strains in laboratory animals. However, the treatment did not affect the levels of other types of bacteria commonly found in the oral cavity. No acute or chronic side-effects were observed in treated rats. The strain was shown to be very stable genetically.
Regulatory Status. In 2005, the Company initiated a Phase I clinical safety trial, and has received permission from the U.S. FDA to begin a second safety trial, which will enlist healthy male subjects in an institutionalized, 12-day study with a 2-month follow-up phase. As part of its global strategy, Oragenics plans to begin the second human trial with the SMaRT technology in Mexico.
About the Author
http://BestDunwoodyDentist.com
Copyright Oragenics, Inc. 2010
|
|
Vintage Car Auto Key Blanks Fits Hillman Minx, Rootes Group, Vauxhall, $0.99 |
|
|
Vintage Car Auto Key Blanks Fits Rootes Group, Leyland, Vauxhall, Hillman-Minx $0.99 |
|
|
Hillman Group Skulls & Roses Lanyard Key Chain 710991 $2.25 |
|
|
The Hillman Group Brown Finish Panel Nails $2.47 |
|
|
The Hillman Group White Finish Panel Nails $2.47 |
|
|
The Hillman Group Dark Oak Finish Panel Nails $2.47 |
|
|
The Hillman Group Black Finish Panel Nails $2.47 |
|
|
The Hillman Group Oak Finish Panel Nails $2.47 |
|
|
The Hillman Group Oak Finish Panel Nails $2.47 |
|
|
The Hillman Group Dark Oak Finish Panel Nails $2.47 |
|
|
The Hillman Group 5MM Brass Shelf Pin $2.50 |
|
|
Hillman Group Camouflage Lanyard Key Chain 711480 $2.66 |
|
|
Hillman Group Flaming Hearts Lanyard Key Chain 710990 $2.66 |
|
|
Key Taylor B79L SR2 GAS Rootes Group, Hillman, Sunbeam $3.16 |
|
|
Taylor Key 64T BR5 Rootes Group,Hillman,Vauxhall,Leland $3.96 |
|
|
2003 Cherished Teddies “Thank You Mom” Priscilla Hillman Enesco Group $6.79 |
|
|
The Hillman Group Flip Flop Key Chain model # 710777 NWT $6.95 |
|
|
Dash Emblem Hillman Rootes Group Year ?? $7.00 |
|
|
1947 Rootes Group Humber, Hillman, Sunbeam-Talbot Original advert $7.84 |
|
|
Penn State NCAA Key Chain NIP Nittany Lions Pennsylvania Metal Hillman Group $7.99 |
|
|
Kansas City Chiefs NFL Key Chain NIP Metal The Hillman Group KC Football $7.99 |
|
|
Diva key blank KW1 66 Glittter Chevron House key Hillman Group Qty 2 $9.00 |
|
|
ROOTS GROUP HILLMAN MINX SUNBEAM RAPIER SIMCA HUMBER BRITISH KEY BLANK S64S $9.95 |
|
|
1949 Print Ad Hillman Minx A Rootes Group Product British Car for $1495 $9.97 |
|
|
5 Bags with 4 in a Bag ~ ~The Hillman Group 5MM Brass Shelf Pin 883866 $9.99 |
|
|
Box Hillman Wedge Bolt Size: 1/2 X 3 Hillman Group NEW $9.99 |
|
|
Denver Broncos NFL Team Keychain Helmet SFK021 Siskiyou Hillman Group 2003 $9.99 |
|
|
The Hillman Group 9 in. x 9 in. Roof Truss Aluminum F-Sign $10.00 |
|
|
1945-64 Beehive Group II Larry Hillman $10.00 |
|
|
1944-63 Beehive Group 2 Maple Leafs Larry Hillman $10.00 |
|
|
NFL Keychain Siskiyou Hillman Group 2003 Helmet Dallas Cowboys Football Team $11.04 |
|
|
NFL Team Denver Broncos Keychain Helmet SFK021 Siskiyou Hillman Group 2003 $11.04 |
|
|
NFL Team Keychain Green Bay Packers Helmet SFK117 Siskiyou Hillman Group 2003 $11.69 |
|
|
NFL Team Keychain New England Patriots Helmet SFK121 Siskiyou Hillman Group 2003 $11.69 |
|
|
NFL Team Denver Broncos Helmet Keychain SFK021 Siskiyou Hillman Group 2003 $11.69 |
|
|
McGuinn Clark & Hillman 1979 Ad- new group $12.00 |
|
|
Dallas Cowboys NFL Keychain Helmet SFK056 Siskiyou Hillman Group 2003 Football $12.99 |
|
|
Green Bay Packers NFL Team Keychain Helmet SFK117 Siskiyou Hillman Group 2003 $12.99 |
|
|
NFL Keychain Dallas Cowboys Helmet SFK056 Siskiyou Hillman Group 2003 Football $12.99 |
|
|
NFL Team Green Bay Packers Helmet Keychain SFK117 Siskiyou Hillman Group 2003 $12.99 |
|
|
New England Patriots NFL Team Keychain Helmet SFK121 Siskiyou Hillman Group 2003 $12.99 |
|
|
ROOTES GROUP RANGE HILLMAN IMP HUSKY MINX PENNANT $14.07 |
|
|
Laurence Hillman PLANETS IN PLAY PENGUIN GROUP, New York c. 2007 SIGNED PB $14.95 |
|
|
Sunbeam Hillman & Rootes Group NOS Factory Suspension Swivel Pin 1200378 * $14.99 |
|
|
Sunbeam Hillman & Rootes Group NOS Rootes Group Speedo Pinion P12075/87 * $15.99 |
|
|
Lot of 4 Hillman Group Vinyl Plastic Signs 2 NO Parking 2 For Rent $16.00 |
|
|
Beautiful 1999 P. Hillman Enesco Group Pedestal #661767 $16.95 |
|
|
Lot of 5 Hillman Group Vinyl Plastic For Rent Signs $17.80 |
|
|
THE HILLMAN SUPER MINX MkIV 1965 OWNERS HANDBOOK IB426/4 ROOTES GROUP $18.84 |
|
|
THE HILLMAN MINX DE LUXE SERIES V OWNERS HANDBOOK 1965 IB381/5 ROOTES GROUP $18.84 |
|
|
Hillman Group Walldog 1-1/2″. Hi-lo Pan-Head Phillips Electrical Anchor Screw 75 $18.99 |
|
|
Sunbeam Hillman & Rootes Group New Factory Brass 3/8 x 24 Exhaust Nuts 9029141 * $18.99 |
|
|
Sunbeam Hillman & Rootes Group NOS Factory Speedo Drive Gear 1236713 * $18.99 |
|
|
Lot of 2 Hillman Group 10-24 x 1-1/2″ Coarse-Thread Machine Bolt $19.00 |
|
|
HILLMAN IMP CAR ROOTES GROUP A3 POSTER PRINT $19.39 |
|
|
OE Owners Handbook Hillman Minx Mark V Rootes Group $19.95 |
|
|
‘NEW’ HILLMAN IMP ROOTES GROUP Handbook 1964, FREE POST $19.99 |
|
|
Sunbeam Hillman & Rootes Group NOS Factory Exhaust Valve Seats 5118034 * $19.99 |
|
|
HILLMAN IMP NORM BEECHEY ROOTES GROUP A3 PICTURE IMAGE POSTER PRINT $19.39 |
|
|
4 rolls of The Hillman Group #4 Braided Picture Hanging Wire $21.00 |
|
|
THE NEW HILLMAN MINX OWNERS HANDBOOK 1956 IB273 ROOTES GROUP $23.56 |
|
|
THE NEW HILLMAN MINX OWNERS HANDBOOK 1957 IB273/3 ROOTES GROUP $23.56 |
|
|
THE NEW HILLMAN MINX SERIES II OWNERS HANDBOOK 1958 IB306/5 ROOTES GROUP $23.56 |
|
|
THE HILLMAN MINX MkV OWNERS HANDBOOK DECEMBER 1951 IB241-2 ROOTES GROUP $23.56 |
|
|
THE HILLMAN MINX MkIV OWNERS HANDBOOK SEPTEMBER 1949 IB228-1 ROOTES GROUP $23.56 |
|
|
THE HILLMAN MINX MkIV OWNERS HANDBOOK MAY 1951 IB228-5 ROOTES GROUP $23.56 |
|
|
1949 Ad Hillman Minx Green Car Rootes Group Kangaroo – ORIGINAL ADVERTISING $23.95 |
|
|
WORKSHOP MANUAL HILLMAN MINX ROOTES GROUP $24.99 |
|
|
Hillman Sunbeam & Rootes Group NOS Factory Crank Starter Nut 111205 * $24.99 |
|
|
1964-67 Beehive Group III Photos #164 Larry Hillman $25.00 |
|
|
HILLMAN: HAWK SIXTEEN AND 80 INSTRUCTION BOOK 1937 ROOTES GROUP PUBLICATION $25.13 |
|
|
~ 1966 The Hillman Minx ~ Owners Handbook by Rootes Group ~ Aust.Postage = $3 $24.25 |
|
|
Lot of 9 Hillman Group Vinyl Plastic Beware of The Dog Signs $36.00 |
|
|
Lot of 9 Hillman Group Vinyl Plastic NO Hunting Signs $36.00 |
|
|
CARS OF ROOTES GROUP SUNBEAM HILLMAN HUMBER SINGER TIGER ALPINE GRAHAM ROBSON GT $39.95 |
|
|
The Hillman Group 48″ Reflective Staff 848638 x 22 $39.99 |
|
|
1944-63 Beehive Group II # Larry Hillman $40.00 |
|
|
Cars of the Rootes Group Sunbeam Hillman Humber Alpine $40.78 |
|
|
Hillman Group LED Illuminated OPEN HG1 Electronic Sign in Refurbished Condition $49.00 |
|
|
2-Knots and Their Groups NEW by Jonathan A. Hillman $59.77 |
|
|
ROOTES GROUP Humber+Hillman+Sunbeam-Talbot+Sunbeam NEW $59.99 |
|
|
1944-63 Beehive Group II Photos #176 Larry Hillman $70.00 |
|
|
CARS OF THE ROOTES GROUP HILLMAN HUMBER SINGER SUNBEAM $133.57 |
